Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel.

ABSTRACT: The antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial peptides (PrAMPs) inhibit the process of bacterial translation. Genome projects allowed to identify immune-related genes encoding animal host defense peptides. Here, using genome mining approach, we discovered a family of proline-rich cathelicidins, named rumicidins. The genes encoding these peptides are widespread among ruminant mammals. Biochemical studies indicated that rumicidins effectively inhibited the elongation stage of bacterial translation. The cryo-EM structure of the Escherichia coli 70S ribosome in complex with one of the representatives of the family revealed that the binding site of rumici

SUBMITTER: Panteleev PV 

PROVIDER: S-EPMC11484942 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature