First-in-human study of D6-[¹⁸F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [¹⁸F]FP-(+)-DTBZ (AV-133).

ABSTRACT:

Background

In the central nervous system, type 2 vesicular monoamine transporters (VMAT2) are responsible for the reuptake of monoamines from synaptic junction back to pre-synaptic terminal vesicles. These transporters are functionally crucial as they reflect the integrity of monoamine neurons. D6-[¹⁸F]FP-(+)-DTBZ, a novel deuterated VMAT2 radioligand, has shown promise as a potential PET tracer for the diagnosis of Parkinson's disease (PD). This study evaluates the biodistribution and dosimetry of D6-[¹⁸F]FP-(+)-DTBZ and includes a head-to-head comparison with its non-deuterated version, [¹⁸F]FP-(+)-DTBZ (AV-133), in healthy individuals and PD patients.

Results

The automated synthesis of D6-[¹⁸F]FP-(+)-DTBZ using the SPE method wa

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11484983 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature