Development and validation of an innovative administration system to facilitate controlled holmium-166 microsphere administration during TARE.

ABSTRACT:

Background

To develop and validate a novel administration device for holmium-166 transarterial radioembolisation (TARE) with the purpose of facilitating controlled fractional microsphere administration for a more flexible and image-guided TARE procedure.

Methods

A Controlled Administration Device (CAD) was developed using MR-conditional materials. The CAD contains a rotating syringe to keep the microspheres in suspension during administration. Different rotational speeds were tested ex vivo to optimise the homogeneity of microsphere fractions administered from the device. The technical performance, accuracy, and safety was validated in three patients in a clinical TARE setting by administering a standard clinical dose in 5 fractions (identifier: NCT05183776). MRI-based dosim

SUBMITTER: van Wijk MWM 

PROVIDER: S-EPMC11484995 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature