Comprehensive pan-cancer analysis of FUTs family as prognostic and immunity markers based on multi-omics data.

ABSTRACT:

Background

The dysregulation of fucosyltransferases (FUTs) contributes to alterations in fucosylated epitope expression, which serve as distinctive features of cancer cells. Nonetheless, a comprehensive elucidation of the prognostic biological marker and therapeutic target of the FUTs family in pan-cancer remains elusive.

Methods

Over 10,000 individuals' profiling information was examined, including information on 750 small molecule drugs, 33 types of cancer, and 24 types of immune cells. We focused on POFUT2's function and applied GSVA (Gene Set Variation Analysis) to calculate the FUT score. Survival and cancer pathways were found to be correlated with this score. After deriving a signature via univariate Cox and LASSO regression, we generated and analyzed the ROC curve an

SUBMITTER: Jia Z 

PROVIDER: S-EPMC11485001 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature