Blood-derived microRNAs are related to cognitive domains in the general population.

ABSTRACT:

Introduction

Blood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel miRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.

Methods

We examined blood-derived miRNAs and miRNA co-expression clusters in relation to cognitive domains, structural magnetic resonance imaging measures, target gene expression, and genetic variants in 2869 participants of a population-based cohort.

Results

Five previously identified and 14 novel miRNAs were associated with cognitive domains. Eleven of these were also associated with cortical thickness and two with hippocampal vol

SUBMITTER: Melas K 

PROVIDER: S-EPMC11485070 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature