Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.

ABSTRACT:

Introduction

Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited.

Methods

Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression.

Results

In weighted models, greater loneliness was associated with microinfarcts, lower episodic and wor

SUBMITTER: Lao P 

PROVIDER: S-EPMC11485071 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature