Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

Magnetic resonance imaging (MRI) segmentation algorithms make it possible to study detailed medial temporal lobe (MTL) substructures as hippocampal subfields and amygdala subnuclei, offering opportunities to develop biomarkers for preclinical Alzheimer's disease (AD).

Methods

We identified the MTL substructures significantly associated with tau-positron emission tomography (PET) signal in 581 non-demented individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI-3). We confirmed our results in our UCLouvain cohort including 110 non-demented individuals by comparing volumes between individuals with different visual Braak's stages and clinical diagnosis.

Results

Four amygdala subnuclei (cortical, central, medial, and accessory basal) were assoc

SUBMITTER: Salman Y 

PROVIDER: S-EPMC11485073 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature