Redox-neutral decarboxylative coupling of fluoroalkyl carboxylic acids <i>via</i> dual metal photoelectrocatalysis.

ABSTRACT: Given the importance and beneficial characteristics of aliphatic CF₃ chiral compounds in modern chemistry, efficient strategies for their synthesis are highly sought after. While α-CF₃ carboxylic acid is an emerging and easily accessible CF₃-containing synthon, its use as a source of fluoroalkyl is highly challenging due to its high oxidation potential. Herein, we disclose a photoelectrocatalytic method for the direct and enantioselective decarboxylative cross-coupling of α-CF₃ carboxylic acids. Key to our approach is the strategic integration of the LMCT-induced decarboxylative process with classical nickel catalysis. This strategy enables the efficient synthesis of aliphatic chiral CF₃ compounds with a broad range of substrates.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11485129 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature