A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome.

ABSTRACT: Copper is a vital micronutrient involved in many biological processes and is an essential component of tumour cell growth and migration. Copper influences tumour growth through a process called cuproplasia, defined as abnormal copper-dependent cell-growth and proliferation. Copper-chelation therapy targeting this process has demonstrated efficacy in several clinical trials against cancer. While the molecular pathways associated with cuproplasia are partially known, genetic heterogeneity across different cancer types has limited the understanding of how cuproplasia impacts patient survival. Utilising RNA-sequencing data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) datasets, we generated gene regulatory networks to identify the critical cuproplasia-related ge

SUBMITTER: Pham VVH 

PROVIDER: S-EPMC11485146 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature