Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder.

ABSTRACT: Recent advances in surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. We used this opportunity to identify neural predictors of clinical state in 12 individuals with treatment-resistant obsessive-compulsive disorder (OCD) receiving deep brain stimulation (DBS) therapy ( NCT05915741 ). We developed our neurobehavioral models based on continuous neural recordings in the region of the ventral striatum in an initial cohort of five patients and tested and validated them in a held-out cohort of seven additional patients. Before DBS activation, in the most symptomatic state, theta/alpha (9 Hz) power evidenced a prominent circadian pattern and a high degree of predictability. In patients with persistent symptoms (non-responders), predictabili

SUBMITTER: Provenza NR 

PROVIDER: S-EPMC11485242 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature