Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.

ABSTRACT: Neurodegenerative diseases are characterized by the abnormal filamentous assembly of specific proteins in the central nervous system¹. Human genetic studies have established a causal role for protein assembly in neurodegeneration². However, the underlying molecular mechanisms remain largely unknown, which is limiting progress in developing clinical tools for these diseases. Recent advances in cryo-electron microscopy have enabled the structures of the protein filaments to be determined from the brains of patients¹. All neurodegenerative diseases studied to date have been characterized by the self-assembly of proteins in homomeric amyloid filaments, including that of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis (ALS) and frontotempora

SUBMITTER: Arseni D 

PROVIDER: S-EPMC11485244 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature