Structure of a fully assembled γδ T cell antigen receptor.

ABSTRACT: T cells in jawed vertebrates comprise two lineages, αβ T cells and γδ T cells, defined by the antigen receptors they express-that is, αβ and γδ T cell receptors (TCRs), respectively. The two lineages have different immunological roles, requiring that γδ TCRs recognize more structurally diverse ligands¹. Nevertheless, the receptors use shared CD3 subunits to initiate signalling. Whereas the structural organization of αβ TCRs is understood^2,3, the architecture of γδ TCRs is unknown. Here, we used cryogenic electron microscopy to determine the structure of a fully assembled, MR1-reactive, human Vγ8Vδ3 TCR-CD3δγε₂ζ₂ complex bound by anti-CD3ε antibody Fab fragments^4,5. The arrangement of CD3 subunits in γδ and αβ TCRs is conserved and, alt

SUBMITTER: Gully BS 

PROVIDER: S-EPMC11485255 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature