Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors.

ABSTRACT: The centrosome is the main microtubule organizing center in stem cells, and its mother centriole, anchored to the cell membrane, serves as the basal body of the primary cilium. Prolonged anchorage of centrosomes and primary cilia to the apical segment of the membrane of apical neural progenitor cells is considered vital for interkinetic nuclear translocation and repetitive cycling in the ventricular zone. In contrast, the basolateral anchorage of primary cilia has been regarded as the first step in delamination and conversion of apical to basal neural progenitor cells or neurons. Using electron microscopy analysis of serial sections, we show that centrosomes, in a fraction of cells, anchor to the basolateral cell membrane immediately after cell division and before development of cilia. In

SUBMITTER: Morozov YM 

PROVIDER: S-EPMC11485267 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature