Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.

ABSTRACT:

Introduction

We examined the associations of polygenic risk score (PRS) with Alzheimer's disease (AD) and plasma biomarkers in the Chinese population.

Methods

This population-based study used baseline data from MIND-China (2018; n = 4873) and follow-up data from dementia-free individuals (2014-2018; n = 2117). We measured AD-related plasma biomarkers in a subsample (n = 1256). Data were analyzed using logistic and Cox regression models.

Results

We developed PRS with (PRS_APOE) and without (PRS_{non- APOE}) apolipoprotein E (APOE) gene. In the longitudinal analysis, PRS_APOE was associated with a multivariable-adjusted hazards ratio of 1.91 (95% CI = 1.13-3.23) for AD. PRS_APOE in combination with demographics yielded di

SUBMITTER: Hou T 

PROVIDER: S-EPMC11485307 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature