Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI.

ABSTRACT:

Introduction

Regional glucose hypometabolism resulting in glutamate loss has been shown as one of the characteristics of Alzheimer's disease (AD). Because the impact of AD varies between the sexes, we utilized glutamate-weighted chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) for high-resolution spatial mapping of cerebral glutamate and investigated subregional changes in a sex-specific manner.

Methods

Eight-month-old male and female AD mice harboring mutant amyloid precursor protein (APP^NL-F/NL-F: n = 36) and wild-type (WT: n = 39) mice underwent GluCEST MRI, followed by proton magnetic resonance spectroscopy (¹H-MRS) in hippocampus and thalamus/hypothalamus using 9.4T preclinical MR scanner.

Results

GluCEST meas

SUBMITTER: Soni ND 

PROVIDER: S-EPMC11485308 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature