Effect of abdominal adipose tissue glucose uptake on brain aging.

ABSTRACT:

Introduction

Abdominal adipose tissue (AT) mass has adverse effects on the brain. This study aimed to investigate the effect of glucose uptake by abdominal AT on brain aging.

Methods

Three-hundred twenty-five participants underwent total-body positron emission tomography scan. Brain age was estimated in an independent test set (n = 98) using a support vector regression model that was built using a training set (n = 227). Effects of abdominal subcutaneous and visceral AT (SAT/VAT) glucose uptake on brain age delta were evaluated using linear regression.

Results

Higher VAT glucose uptake was linked to negative brain age delta across all subgroups. Higher SAT glucose uptake was associated with negative brain age delta in lean individuals. In contrast, increased SAT gluco

SUBMITTER: Lu W 

PROVIDER: S-EPMC11485312 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature