The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease.

ABSTRACT: Neurogenesis persists throughout adulthood in the hippocampus and contributes to specific cognitive functions. In Alzheimer's disease (AD), the hippocampus is affected by pathology and functional impairment early in the disease. Human AD patients have reduced adult hippocampal neurogenesis (AHN) levels compared to age-matched healthy controls. Similarly, rodent AD models show a decrease in AHN before the onset of the classical hallmarks of AD pathology. Conversely, enhancement of AHN can protect against AD pathology and ameliorate memory deficits in both rodents and humans. Therefore, impaired AHN may be a contributing factor of AD-associated cognitive decline, rather than an effect of it. In this review we outline the regulation and function of AHN in healthy individuals, and highlight th

SUBMITTER: Geigenmuller JN 

PROVIDER: S-EPMC11485317 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature