An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba.

ABSTRACT:

Background

The number of people with dementia is increasing in Japan, and establishing evidence for preventing dementia is necessary.

Methods

This study was a randomized controlled trial in cognitively normal community-dwelling older adults aged 65 to 85 with diabetes and/or hypertension. Participants were randomly assigned in a 1:1 ratio. The intervention group underwent 90 min of group-based weekly physical exercise, cognitive training, nutritional counseling, and vascular risk management for 18 months. The primary endpoint was the change in a cognitive composite score calculated by averaging the z-scores of seven neuropsychological tests from baseline to 18 months.

Results

We randomly assigned 203 participants to two groups, and 178 (87.7%) completed the 18-month f

SUBMITTER: Oki Y 

PROVIDER: S-EPMC11485327 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature