Enhanced detection of skull-base bone invasion in nasopharyngeal carcinoma: the supplementary diagnostic value of ¹⁸fluorine-sodium fluoride (¹⁸F-NaF) positron emission tomography/computed tomography (PET/CT) combined with magnetic resonance imaging (MRI).

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal mucosa, the lateral wall of the nasopharynx. A significant challenge in NPC management is skull-base bone invasion (SBBI), which affects prognosis and treatment planning. Magnetic resonance imaging (MRI) is the primary diagnostic tool for SBBI in NPC patients; however, the detection of SBBI can be challenging due to skull-base complexity and overlapping MRI signals. ¹⁸fluorine-sodium fluoride (¹⁸F-NaF) positron emission tomography/computed tomography (PET/CT) is an emerging imaging technique that has shown promise in detecting osseous lesions. This cohort study aimed to assess the supplementary diagnostic value of ¹⁸F-NaF PET/CT in detecting SBBI in NPC patients compared to t

SUBMITTER: Liang M 

PROVIDER: S-EPMC11485363 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature