Omics-derived biological modules reflect metabolic brain changes in Alzheimer's disease.

ABSTRACT:

Introduction

Brain glucose hypometabolism, indexed by the fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET) imaging, is a metabolic signature of Alzheimer's disease (AD). However, the underlying biological pathways involved in these metabolic changes remain elusive.

Methods

Here, we integrated [¹⁸F]FDG-PET images with blood and hippocampal transcriptomic data from cognitively unimpaired (CU, n = 445) and cognitively impaired (CI, n = 749) individuals using modular dimension reduction techniques and voxel-wise linear regression analysis.

Results

Our results showed that multiple transcriptomic modules are associated with brain [¹⁸F]FDG-PET metabolism, with the top hits being a protein serine/threonine kinase activity gene cl

SUBMITTER: Povala G 

PROVIDER: S-EPMC11485394 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature