Translational evaluation of Gelsectan^® effects on gut barrier dysfunction and visceral pain in animal models and irritable bowel syndrome with diarrhoea.

ABSTRACT:

Background

Gelsectan^® is a formulation of xyloglucan (XG), pea protein, grape seed extract (PPGS) and xylo-oligosaccharides (XOS). Our aim was to examine the effect of Gelsectan^® on rectal sensitivity in an animal model, abdominal pain in irritable bowel syndrome with diarrhoea (IBS-D) subjects and intestinal permeability in both conditions.

Methods

Animals: Wistar rats received gavage with XOS, XG + PPGS or XG + PPGS + XOS, as a single dose or for 7 days before a partial restraint stress (PRS). Visceromotor response to rectal distension and total gut paracellular permeability to ⁵¹Cr-EDTA were assessed. Humans: IBS-D and control patients were involved. After initial colonoscopy with biopsy sampling Gelsectan® was administered to IBS-D patien

SUBMITTER: Inczefi O 

PROVIDER: S-EPMC11485395 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature