Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease.

ABSTRACT:

Background

The Mnemonic Similarity Task (MST) is a popular memory task designed to assess hippocampal integrity. We assessed whether analyzing MST performance using a multinomial processing tree (MPT) cognitive model could detect individuals with elevated Alzheimer's disease (AD) biomarker status prior to cognitive decline.

Method

We analyzed MST data from >200 individuals (young, cognitively healthy older adults and individuals with mild cognitive impairment [MCI]), a subset of which also had existing cerebrospinal fluid (CSF) amyloid beta (Aβ) and phosphorylated tau (pTau) data using both traditional and model-derived approaches. We assessed how well each could predict age group, memory ability, MCI status, Aβ, and pTau status using receiver operating characteristic analys

SUBMITTER: Vanderlip CR 

PROVIDER: S-EPMC11485396 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature