Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression.

ABSTRACT:

Introduction

Normal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early Alzheimer's disease (AD) pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this study was to use samples from this cohort to identify cerebrospinal fluid  (CSF) biomarkers for AD-related central nervous system (CNS) pathophysiologic changes using tissue and fluids with early pathology, free of post mortem artifact.

Methods

We analyzed Simoa, proteomic, and metabolomic CSF data from 81 patients with previously documented pathologic and transcriptomic changes.

Results

AD pathology on biopsy correlates with CSF β-amyloid-42/40, neurofilament light chain (NfL), and phospho-tau-181(p-tau181)/β-amyloid-42, while several

SUBMITTER: Ropri AS 

PROVIDER: S-EPMC11485399 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature