Standardized statistical framework for comparison of biomarkers: Techniques from ADNI.

ABSTRACT:

Introduction

Well-chosen biomarkers have the potential to increase the efficiency of clinical trials and drug discovery and should show good precision as well as clinical validity.

Methods

We suggest measures that operationalize these criteria and describe a general approach that can be used for inference-based comparisons of biomarker performance. The methods are applied to measures obtained from structural magnetic resonance imaging (MRI) from individuals with mild dementia (n = 70) or mild cognitive impairment (MCI; n = 303) enrolled in the Alzheimer's Disease Neuroimaging Initiative.

Results

Ventricular volume and hippocampal volume showed the best precision in detecting change over time in both individuals with MCI and with dementia. Differences in clinical valid

SUBMITTER: Harvey DJ 

PROVIDER: S-EPMC11485401 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature