Contribution of alpha-synuclein pathology to cerebral glucose metabolism in patients with amnestic MCI.

ABSTRACT:

Introduction

The in vivo detection of mixed Alzheimer's disease (AD) and α-synuclein (αSyn) pathology is important for clinical management and prognostic stratification. We investigated the contribution of αSyn pathology, detected by cerebrospinal fluid (CSF) seed amplification assay (αSyn SAA), on [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) pattern in subjects with amnestic mild cognitive impairment (aMCI).

Methods

We included 562 aMCI participants and 204 cognitively normal controls (CN) with available αSyn SAA and cerebral metabolic rate for glucose utilization (rCMRgl) data.

Results

24% of aMCI cases were positive (+) for CSF αSyn SAA. Compared to CN, both αSyn+ and negative (-) aMCI participants showed reductions in rCMRgl within AD typical re

SUBMITTER: Abu-Rumeileh S 

PROVIDER: S-EPMC11485405 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature