Renal function and risk of dementia: a Mendelian randomization study.

ABSTRACT:

Background

The burgeoning recognition of the nexus between renal functionality and the prevalence of dementia has precipitated a surge in research endeavors. This study aims to substantiate the causal relationship between kidney functionality and dementia.

Methods

We utilized clinical renal function metrics from the Chronic Kidney Disease Genetics (CKDGen) Consortium and diverse dementia types (Alzheimer's disease [AD] and vascular dementia) from the FinnGen Biobank by using Mendelian randomization analysis. At the stratum of genetic susceptibility, we tested the causal relationship between variations index in renal function and the occurrence of dementia. Inverse-variance weighted (IVW) method was the main analysis, and several supplementary analyses and sensitivity analyse

SUBMITTER: Huang H 

PROVIDER: S-EPMC11485685 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature