Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation.

ABSTRACT: Infection with the protozoan parasite Giardia duodenalis (syn. intestinalis, lamblia) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood. Mucus consists primarily of densely glycosylated mucin glycoproteins. Mucin O-glycans influence mucus barrier properties and mucin-microbe interactions and are frequently altered during disease. In this study, we observed time-dependent and regiospecific alterations to intestinal mucin glycosylation patterns and the expression of mucin-associated glycosyltransferase genes during Giardia infection. Glycosylation alterations were observed in Giardia-infected mice in the upper small intestine, the site of parasite colonization, and in the dis

SUBMITTER: Fekete E 

PROVIDER: S-EPMC11485787 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature