Clostridium sporogenes-derived metabolites protect mice against colonic inflammation.

ABSTRACT: Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal Clostridium sporogenes possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate and isovalerate and the short-chain fatty acids (SCFAs) acetate and propionate. Mono-colonization of germ-free mice with C. sporogenes (CS mice) affected colonic mucosal immune cell phenotypes, including up-regulation of Il22 gene expression, and increased abundance of transcriptionally active colonic tuft cells and Foxp3⁺ regulatory T cells (Tregs). In DSS-induced colitis, conventional mice suffered severe inflam

SUBMITTER: Krause FF 

PROVIDER: S-EPMC11485882 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature