Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019-2023).

ABSTRACT: Protein kinases play a key role in cellular signaling pathways including proliferation, apoptosis, inflammation and immune regulation. Therefore, targeting kinases with small molecules has emerged as a therapeutic potential in cancers and other diseases including inflammatory and autoimmune disorders. The main chemical motifs of the available small molecule kinase inhibitors are heterocyclic, nitrogen-containing and six-membered rings including pyrazine. Several potent and selective pyrazine-based kinase inhibitors have been developed and progressed into clinical trials. The data of clinical application of kinase inhibitors demonstrate good clinical activity with manageable toxicity in several relapse-resistant malignancies and severe to moderate immunological disorders. All pyrazine-based

SUBMITTER: Alsfouk A 

PROVIDER: S-EPMC11485930 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature