Regulation of the NF-κB/NLRP3 signalling pathway by <i>Shenghui Yizhi</i> decoction reduces neuroinflammation in mice with Alzheimer's disease.

ABSTRACT:

Background

Shenghui Yizhi Decoction (SHYZD) has exhibited the capacity to enhance cognitive function and learning abilities in individuals diagnosed with Alzheimer's disease (AD) while ameliorating pre-existing neuroinflammation. Nevertheless, the precise mechanism underlying its therapeutic effects on AD remains to be elucidated.

Methods

Twenty-four male SAMP8 mice were randomly divided into three groups, and eight male SAMR1 mice were used as a blank control, to examine their learning and spatial memory abilities. The expression of amyloid β1-42 (Aβ1-42) was detected by immunohistochemical staining of hippocampal tissue. ELISA was used to detect the interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) expressions. Real time PCR was used

SUBMITTER: Wang P 

PROVIDER: S-EPMC11486153 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature