Molecular docking, derivatization, characterization and biological assays of amantadine.

ABSTRACT: Background: Derivatization has been tremendously utilized in the field of drug discovery for optimizing the pharmacological properties and improving safety, efficacy and selectivity.Methodology: Schiff's bases (AD1-AD11) are synthesized through amantadine condensation with different aldehydes and ketones. Fourier transform infrared, ¹H NMR, ¹³C NMR, TLC, liquid chromatography mass spectrometry analysis, in silico studies, molecular docking and antiviral activity through hemagglutinin test were performed for evaluation of new compounds.Results: AD2, 3 and 9-11 showed greater antiviral activity than the parent drug. Among all derivatives, AD2 and AD3 exhibited good potential against α-amylase while AD7 and AD10 showed stronger inhibition agai

SUBMITTER: Yasmeen Z 

PROVIDER: S-EPMC11486214 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature