Reverse-engineered models reveal differential membrane properties of autonomic and cutaneous unmyelinated fibers.

ABSTRACT: Unmyelinated C-fibers constitute the vast majority of axons in peripheral nerves and play key roles in homeostasis and signaling pain. However, little is known about their ion channel expression, which controls their firing properties. Also, because of their small diameters (~ 1 μm), it has not been possible to characterize their membrane properties using voltage clamp. We developed a novel library of isoform-specific ion channel models to serve as the basis functions of our C-fiber models. We then developed a particle swarm optimization (PSO) framework that used the isoform-specific ion channel models to reverse engineer C-fiber membrane properties from measured autonomic and cutaneous C-fiber conduction responses. Our C-fiber models reproduced experimental conduction velocity, chronaxie,

SUBMITTER: Thio BJ 

PROVIDER: S-EPMC11486378 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature