Distinct cellular and junctional dynamics independently regulate the rotation and elongation of the embryonic gut in Drosophila.

ABSTRACT: Complex organ structures are formed with high reproducibility. To achieve such intricate morphologies, the responsible epithelium undergoes multiple simultaneous shape changes, such as elongation and folding. However, these changes have typically been assessed separately. In this study, we revealed how distinct shape changes are controlled during internal organ morphogenesis. The Drosophila embryonic hindgut undergoes left-right asymmetric rotation and anteroposterior elongation in a tissue-autonomous manner driven by cell sliding and convergent extension, respectively, in the hindgut epithelia. However, the regulation of these processes remains unclear. Through genetic analysis and live imaging, we demonstrated that cell sliding and convergent extension are independently regulated by Myos

SUBMITTER: Inaki M 

PROVIDER: S-EPMC11486408 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature