The optimal spatially-dependent control measures to effectively and economically eliminate emerging infectious diseases.

ABSTRACT: Non-pharmaceutical interventions (NPIs) are effective in mitigating infections during the early stages of an infectious disease outbreak. However, these measures incur significant economic and livelihood costs. To address this, we developed an optimal control framework aimed at identifying strategies that minimize such costs while ensuring full control of a cross-regional outbreak of emerging infectious diseases. Our approach uses a spatial SEIR model with interventions for the epidemic process, and incorporates population flow in a gravity model dependent on gross domestic product (GDP) and geographical distance. We applied this framework to identify an optimal control strategy for the COVID-19 outbreak caused by the Delta variant in Xi'an City, Shaanxi, China, between December 2021 and J

SUBMITTER: Xia F 

PROVIDER: S-EPMC11486435 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature