Impaired <i>Mycobacterium tuberculosis</i>-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.

ABSTRACT:

Background

Efforts to eradicate tuberculosis (TB) are threatened by diabetes mellitus (DM), which confers a 3-fold increase in the risk of TB disease. The changes in the memory phenotypes and functional profiles of Mycobacterium tuberculosis (Mtb)-specific T cells in latent TB infection (LTBI)-DM participants remain poorly characterised. We, therefore, assessed the effect of DM on T-cell phenotype and function in LTBI and DM clinical groups.

Methods

We compared the memory phenotypes and function profiles of Mtb-specific CD4⁺ and CD8⁺ T cells among participants with LTBI-DM (n=21), LTBI-only (n=17) and DM-only (n=16). Peripheral blood mononuclear cells (PBMCs) were stimulated with early secretory antigenic 6 kDa (ESAT-6) and culture

SUBMITTER: Ssekamatte P 

PROVIDER: S-EPMC11486641 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature