Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle.

ABSTRACT: Exosomes are promising therapeutics for tissue repair and regeneration to induce and guide appropriate immune responses in dystrophic pathologies. However, manipulating exosomes to control their biodistribution and targeting them in vivo to achieve adequate therapeutic benefits still poses a major challenge. Here we overcome this limitation by developing an externally controlled delivery system for primed annexin A1 myo-exosomes (Exo^myo). Effective nanocarriers are realized by immobilizing the Exo^myo onto ferromagnetic nanotubes to achieve controlled delivery and localization of Exo^myo to skeletal muscles by systemic injection using an external magnetic field. Quantitative muscle-level analyses revealed that macrophages dominate the uptake of Exo^myo

SUBMITTER: Villa C 

PROVIDER: S-EPMC11486659 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature