SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression.

ABSTRACT:

Background

This study investigated the expression and role of Synaptosome associated protein 25 (SNAP25) in high-grade neuroendocrine carcinoma (HGNEC).

Methods

We used differentially expressed analysis and weighted gene co-expression network analysis (WGCNA) to identify key genes and modules in HGNEC. KEGG and GO analyses helped understand these genes' roles, and ROC curves assessed their diagnostic value. We also studied SNAP25's relation to immune infiltration and confirmed findings with in vitro and vivo experiments and datasets.

Results

WGCNA identified 595 key genes related to pathways like MAPK signaling, GABAergic synapse, and cancer-related transcriptional misregulation. Top genes included SNAP25, MYC, NRXN1, GAD2, and SYT1. SNAP25 was notably associat

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11486671 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature