Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model.

ABSTRACT: Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, functional connectivity is decreased after injury. Recovery of connectivity after TBI is associated with improved cognition and memory, suggesting an important link between connectivity and functional outcome. We examined widespread alterations in functional connectivity following TBI using simultaneous widefield mesoscale GCaMP7c calcium imaging and electrocorticography (ECoG) in mice injured using the controlled cortical impact (CCI) model of TBI. Combining CCI with widefield cortical imaging provides us with unprecedented access to characterize network con

SUBMITTER: Bottom-Tanzer S 

PROVIDER: S-EPMC11486687 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature