Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.

ABSTRACT:

Objectives

The role of trimethylamine oxide (TMAO) in patients with cognitive impairment remains controversial. This study aimed to assess the association between TMAO and its precursors and the prevalence of cognitive impairment.

Methods

PubMed, Embase, and Web of Science databases were searched for studies that met the inclusion criteria from their inception to 14 September 2024, and references were manually searched to identify any additions. Odds ratio (OR) was assessed by random-effects modeling, subgroup analyses to identify potential sources of heterogeneity, and the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) Inventory for qualitative evaluation.

Results

Nine studies involving 82,246 participants were included in the

SUBMITTER: Long C 

PROVIDER: S-EPMC11486729 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature