Causal association between thyroid function and the risk of infertility: a Mendelian randomization study.

ABSTRACT:

Objectives

Thyroid dysfunction is commonly associated with the risk of infertility in both females and males. However, recent randomized controlled trials have demonstrated that thyroid function levels in females are not significantly related to infertility, and evidence on the association between male thyroid function and infertility is limited. We aim to investigate the association between thyroid function levels and infertility in both females and males.

Method

A two-sample Mendelian randomization study was conducted using four methods, with the inverse variance weighted method (IVW) as the primary approach. Data on thyroid function as the exposure were obtained from the ThyroidOmics Consortium and UK Biobank, including over 700,000 individuals from a large meta-analysis

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11486735 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature