Targeting exercise-related genes and placental growth factor for therapeutic development in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Human cancers, including head and neck squamous cell carcinoma (HNSCC), are complex and heterogeneous diseases driven by uncontrolled cell growth and proliferation. Post-translational modifications (PTMs) of proteins play a crucial role in cancer progression, making them a promising target for pharmacological intervention. This study aims to identify key exercise-related genes with prognostic value in HNSCC through comprehensive bioinformatics analysis, with a particular focus on the therapeutic potential of placental growth factor (PIGF).

Methods

Transcriptome data for HNSCC were obtained from The Cancer Genome Atlas (TCGA) database. Differently expressed genes (DEGs) were identified and analyzed for their prognostic significance. Exercise-related gene sets were

SUBMITTER: Shi Q 

PROVIDER: S-EPMC11486741 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature