Association of clozapine with structural and resting-state functional abnormalities of the hippocampus in chronic schizophrenia.

ABSTRACT:

Introduction

Abnormalities in the hippocampus have been extensively reported in schizophrenia research. However, inconsistent findings exist, and how structural and functional abnormalities of the hippocampus are associated with clinical symptoms in schizophrenia, especially concerning clozapine treatment, remains uncertain.

Methods

We recruited 52 patients with schizophrenia, each with an illness duration of at least 5 years, and categorized them based on clozapine treatment. T1-weighted images and resting-state functional magnetic resonance imaging scans were obtained and analyzed to perform group comparisons of the structural and functional changes in the hippocampus. Volumes of the hippocampal subregions, as well as resting-state functional connectivity maps from these a

SUBMITTER: Joo SW 

PROVIDER: S-EPMC11486750 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature