Effects of Tanreqing injection on the gut microbiota in healthy volunteers.

ABSTRACT:

Objectives

Many studies have confirmed that antibacterial agents can disrupt the human gut microbiota. In China, Tanreqing injection (TRQ) is a drug with antibacterial activity that is widely used in the treatment of respiratory infections. However, its specific influence on gut microbiota remains unclear. This study aimed to investigate the effect of TRQ on the gut microbiota of healthy volunteers.

Methods

Twelve healthy adults received 20 ml of TRQ intravenously daily for 7 consecutive days. At six timepoints (Pre, on D1, D3, D5, D7 and follow-up visit) fecal samples were collected and analyzed using 16S rRNA gene sequencing.

Results

Eleven people were included in the analysis finally. TRQ did not significantly alter gut microbiota diversity or richness (Shannon and

SUBMITTER: Li S 

PROVIDER: S-EPMC11486765 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature