Prognostic significance and biological implications of SM-like genes in mantle cell lymphoma.

ABSTRACT:

Background

SM-like (LSM) genes a family of RNA-binding proteins, are involved in mRNA regulation and can function as oncogenes by altering mRNA stability. However, their roles in B-cell progression and tumorigenesis remain poorly understood.

Methods

We analyzed gene expression profiles and overall survival data of 123 patients with mantle cell lymphoma (MCL). The LSM index was developed to assess its potential as a prognostic marker of MCL survival.

Results

Five of the eight LSM genes were identified as potential prognostic markers for survival in MCL, with particular emphasis on the LSM.index. The expression levels of these LSM genes demonstrated their potential utility as classifiers of MCL. The LSM.index-high group exhibited both poorer survival rates and lower RNA

SUBMITTER: He X 

PROVIDER: S-EPMC11486876 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature