Interference length reveals regularity of crossover placement across species.

ABSTRACT: Crossover interference is a phenomenon that affects the number and positioning of crossovers in meiosis and thus affects genetic diversity and chromosome segregation. Yet, the underlying mechanism is not fully understood, partly because quantification is difficult. To overcome this challenge, we introduce the interference length L_int that quantifies changes in crossover patterning due to interference. We show that it faithfully captures known aspects of crossover interference and provides superior statistical power over previous measures such as the interference distance and the gamma shape parameter. We apply our analysis to empirical data and unveil a similar behavior of L_int across species, which hints at a common mechanism. A recently proposed coarsening model gen

SUBMITTER: Ernst M 

PROVIDER: S-EPMC11487058 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature