Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection.

ABSTRACT: Infection is a devastating post-surgical complication, often requiring additional procedures and prolonged antibiotic therapy. This is especially relevant for craniotomy and prosthetic joint infections (PJI), both of which are characterized by biofilm formation on the bone or implant surface, respectively, with S. aureus representing a primary cause. The local tissue microenvironment likely has profound effects on immune attributes that can influence treatment efficacy, which becomes critical to consider when developing therapeutics for biofilm infections. However, the extent to which distinct tissue niches influence immune function during biofilm development remains relatively unknown. To address this, we compare the metabolomic, transcriptomic, and functional attributes of leukocytes in

SUBMITTER: Van Roy Z 

PROVIDER: S-EPMC11487069 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature