Discovery of plasma biomarkers related to blood-brain barrier dysregulation in Alzheimer's disease.

ABSTRACT:

Introduction

Blood-based biomarkers are quantitative, non-invasive diagnostic tools. This study aimed to identify candidate biomarkers for Alzheimer's disease (AD) using publicly available omics datasets, using the hypothesis that with blood-brain barrier dysfunction in AD, brain-synthesized proteins can leak into plasma for detection.

Methods

Differential abundance results of plasma and brain proteomic datasets were integrated to obtain a list of potential biomarkers. Biological validity was investigated with intercellular communication and gene regulatory analyses on brain single-cell transcriptomics data.

Results

Five proteins (APOD, B2M, CFH, CLU, and C3) fit biomarker criteria. 4 corresponding transcripts (APOD, B2M, CLU, and C3) were overexpressed in AD astrocyt

SUBMITTER: Dan YR 

PROVIDER: S-EPMC11487119 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature