Multimodal gradients of basal forebrain connectivity across the neocortex.

ABSTRACT: Cortical cholinergic projections originate from subregions of the basal forebrain (BF). To examine its organization in humans, we computed multimodal gradients of BF connectivity by combining 7 T diffusion and resting state functional MRI. Moving from anteromedial to posterolateral BF, we observe reduced tethering between structural and functional connectivity gradients, with the lowest tethering in the nucleus basalis of Meynert. In the neocortex, this gradient is expressed by progressively reduced tethering from unimodal sensory to transmodal cortex, with the lowest tethering in the midcingulo-insular network, and is also spatially correlated with the molecular concentration of VAChT, measured by [¹⁸F]fluoroethoxy-benzovesamicol (FEOBV) PET. In mice, viral tracing of BF cholin

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC11487139 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature