The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission.

ABSTRACT: Bacteriophages are influential within the human gut microbiota, yet they remain understudied relative to bacteria. This is a limitation of studies on fecal microbiota transplantation (FMT) where bacteriophages likely influence outcome. Here, using metagenomics, we profile phage populations - the phageome - in individuals recruited into two double-blind randomized trials of FMT in ulcerative colitis. We leverage the trial designs to observe that phage populations behave similarly to bacterial populations, showing temporal stability in health, dysbiosis in active disease, modulation by antibiotic treatment and by FMT. We identify a donor bacteriophage putatively associated with disease remission, which on genomic analysis was found integrated in a bacterium classified to Oscillospiraceae, pr

SUBMITTER: Majzoub ME 

PROVIDER: S-EPMC11487140 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature