Apolipoprotein B-48 and late graft failure in kidney transplant recipients.

ABSTRACT:

Introduction

Transplant vasculopathy resembles atherosclerotic plaque formation and is a major contributor to late graft failure in kidney transplant recipients (KTR). Remnant lipoproteins and associated triglycerides are causal risk factors for atherosclerotic plaques and have been implicated in late kidney graft failure. However, whether remnants derived from liver (containing apolipoprotein [apo] B100) or intestine (containing apoB48) are clinically more important is unclear. The current study investigated the association between baseline fasting apoB48 levels and late kidney graft failure.

Methods

481 KTR with a functioning graft for at least 1 year were included in this retrospective, observational longitudinal single center cohort study. The primary endpoint was death-

SUBMITTER: Szili-Torok T 

PROVIDER: S-EPMC11487158 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature